Treatment of Klebsiella pneumoniae
with Nano Silver (nAg-NPs)
Nano silver has shown promise in treating Klebsiella pneumoniae infections, particularly those resistant to traditional antibiotics. Here are some key points regarding its use:
Nano Silver (nAg-NPs): Studies have demonstrated that nano silver can effectively inhibit the growth of Klebsiella pneumoniae, especially those producing extended-spectrum β-lactamases (ESBLs). For example, concentrations of 0.5 g/mL and above have shown 100% bactericidal effects on ESBL K. pneumoniae.
Mechanism of Action: Nano silver has been found to alter the morphology of K. pneumoniae, indicating that it disrupts the bacterial structure and function, leading to its death.
In Vivo Studies: In animal models, nano silver has shown significant efficacy in reducing the pathogenicity of K. pneumoniae, indicating its potential for clinical application.
Synergistic Effects: Combining nano silver with other antibiotics like oxytetracycline or imipenem has been shown to enhance their antibacterial activity, reducing the required concentrations of these antibiotics.
Clinical Trials: A clinical study involving 88 patients found that the use of nano silver in combination with comprehensive nursing interventions led to a significant reduction in the incidence of risk events and increased patient satisfaction. https://pubmed.ncbi.nlm.nih.gov/32384953/
https://www.byronherbalist.com.au/gut-health/klebsiella-bacterial-dysbiosis/